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Not to be confused with 1-Formyl-LSD.

1F-LSD, also known as 1-(furan-2-carbonyl)-LSD, 1-(2-furoyl)-LSD, or SYN-L-005, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).[1][2] It is thought to act as a prodrug of LSD.[1][2] The drug interacts with serotonin receptors, including the serotonin 5-HT2A receptor, and produces the head-twitch response in rodents, with about 3-fold lower potency than LSD.[1] It hydrolyzes into LSD in rodents.[1] 1F-LSD was patented in 2024[2] and was first described in the scientific literature in 2025.[1] It has been encountered as a novel designer drug in Germany and Japan.[1]

Use and effects

See also: LSD § Uses, and LSD § Effects

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

Chemistry

Analogues

Analogues of 1F-LSD include 1P-LSD, 1cP-LSD, 1B-LSD, 1S-LSD, and 1T-LSD, among others.

Society and culture

Canada

1F-LSD is not an explicitly nor implicitly controlled substance in Canada as of 2025.[3]

United States

1F-LSD is not an explicitly controlled substance in the United States.[4] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

See also

References

  1. ^ a b c d e f Brandt SD, Kavanagh PV, Gare S, Elliott SP, Stratford A, Halberstadt AL (August 2025). “Analytical and Pharmacological Characterization of 1-(Furan-2-Carbonyl)-LSD (1F-LSD) and Comparison With 1-(Thiophene-2-Carbonyl)-LSD (1T-LSD)”. Drug Test Anal. 17 (8): 1283–1293. doi:10.1002/dta.3829. PMC 12319525. PMID 39624022.
  2. ^ a b c WO 2024/028495, Stratford A, Williamson JP, ”Prodrugs of Substituted Ergolines”, published 8 February 2024, assigned to Synex Holdings BV 
  3. ^ “Controlled Drugs and Substances Act”. Department of Justice Canada. 5 December 2025. Retrieved 20 January 2026.
  4. ^ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) (PDF), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026