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2-Oxoadipic acid, also known as α-ketoadipic acid, is an intermediate in the metabolism of lysine and tryptophan.[3][4] The conjugate base and carboxylate is 2-oxoadipate or α-ketoadipate, which is the biochemically relevant form. Glutaric acid is naturally produced by chain extension of α-ketoglutarate to 2-oxoadipic acid.[5]

See also

References

  1. ^ 2-oxoadipate – Compound Summary, PubChem.
  2. ^ “Alpha-ketoadipic acid”. The PubChem Project. National Center for Biotechnology Information.
  3. ^ Voet, Donald; Voet, Judith G. (2011). Biochemistry (4th ed.). Hoboken, NJ: Wiley. pp. 1040–1043. ISBN 978-0-470-57095-1.
  4. ^ Dobrota, Dušan (2016). Lekárska biochémia [Medical biochemistry] (in Slovak) (2nd ed.). Martin: Osveta. pp. 329–330, 335–337. ISBN 978-80-8063-444-5.
  5. ^ Wang, Jian; Wu, Yifei; Sun, Xinxiao; Yuan, Qipeng; Yan, Yajun (2017). “De Novo Biosynthesis of Glutarate via α-Keto Acid Carbon Chain Extension and Decarboxylation Pathway in Escherichia coli“. ACS Synthetic Biology. 6 (10): 1922–1930. doi:10.1021/acssynbio.7b00136. PMID 28618222.