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2-Methyl-iPALT, or 2-methyl-ALiPT, also known as 2-methyl-N-isopropyl-N-allyltryptamine or by its developmental code name ASR-3002, is a serotonin receptor modulator of the tryptamine family.[1] It is the 2-methyl derivative of iPALT.[1] The drug is very similar in structure to 2-methyl-DiPT, which Alexander Shulgin hypothesized would be a DiPT-like selective auditory hallucinogen but never synthesized nor tested.[1]

Pharmacology

Pharmacodynamics

2-Methyl-iPALT is a non-selective serotonin receptor agonist, including of the serotonin 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT6 receptors, but not of the serotonin 5-HT1A receptor.[1] However, it shows rather low, micromolar potency for most of these actions, with for example 264-fold lower potency as a serotonin 5-HT2A receptor agonist than the known psychedelic drug 5-MeO-iPALT (ASR-3001).[1] The drug is inactive as a monoamine reuptake inhibitor.[1]

Chemistry

Synthesis

The chemical synthesis of 2-methyl-iPALT has been described.[1]

Analogues

Analogues of 2-methyl-iPALT include 5-MeO-iPALT (ASR-3001), 4-HO-iPALT, 2-methyl-DMT, 2-methyl-DET, and 2-methyl-DiPT, among others.[1][2]

History

2-Methyl-iPALT was patented by the Alexander Shulgin Research Institute (ASRI) in 2024.[1]

See also

References

  1. ^ a b c d e f g h i US 20240277665A1, Daley PF, Cozzi NV, Callaway WB, ”Asymmetric allyl tryptamines”, issued 4 March 2024, assigned to Alexander Shulgin Research Institute Inc. 
  2. ^ Shulgin A, Shulgin A (September 1997). TiHKAL: The Continuation. Berkeley, California: Transform Press. ISBN 0-9630096-9-9. OCLC 38503252.