6-Phosphogluconic acid (with conjugate base 6-phosphogluconate) is a phosphorylated sugar acid which appears in the pentose phosphate pathway and the Entner–Doudoroff pathway.[1]
During the oxidative phase of the pentose phosphate pathway, it is formed from 6-phosphogluconolactone by 6-phosphogluconolactonase, and in turn, it is converted to ribulose 5-phosphate by phosphogluconate dehydrogenase, in an oxidative decarboxylation which also produces NADPH.
In those microorganisms which host the Entner-Doudoroff pathway, 6-phosphogluconic acid may also be acted upon by 6-phosphogluconate dehydratase to produce 2-keto-3-deoxy-6-phosphogluconate.
See also
References
- ^ Romano, A. H.; Conway, T. (1996-07-01). “Evolution of carbohydrate metabolic pathways”. Research in Microbiology. 147 (6): 448–455. doi:10.1016/0923-2508(96)83998-2. ISSN 0923-2508. PMID 9084754.