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6-Phosphogluconolactone is an intermediate in the pentose phosphate pathway (PPP).

In the PPP, it is produced from glucose-6-phosphate by glucose-6-phosphate dehydrogenase.[1][2]

2D representation of the chemical structure of Q36461529.
Glucose 6-phosphonic acid
+ NADP+
 
 
 
H+
Reversible left-right reaction arrow with minor forward product(s) to top right and minor reverse substrate(s) from bottom right
 
H+
 
2D representation of the chemical structure of Q245503.
6-Phosphogluconolactone
+ NADPH
 


It is then converted to 6-Phosphogluconic acid by 6-phosphogluconolactonase.

References

  1. ^ Enzyme 1.1.1.49 at KEGG Pathway Database.
  2. ^ Kotaka M, Gover S, Vandeputte-Rutten L, Au SW, Lam VM, Adams MJ (May 2005). “Structural studies of glucose-6-phosphate and NADP+ binding to human glucose-6-phosphate dehydrogenase” (PDF). Acta Crystallographica D. 61 (Pt 5): 495–504. doi:10.1107/S0907444905002350. PMID 15858258.