February 20 – The Battle of Hard is fought near the village of Hard in modern-day western Austria as the Swiss Confederacy defeats the troops of the Holy Roman Empire in the first large-scale confrontation of the Swabian War.[3]
April 20 – The Swiss Confederacy defeats the forces of the Holy Roman Empire in the Battle of Frastanz, with more than 2,000 Imperial troops killed.[6]
April 30 – The University of Valencia is founded in Spain with the passage of the University Statutes by the magistrates of Valencia.[7]
June 1 – Pedro Alonso Niño, who had accompanied Columbus on his first voyage to the New World in 1492, departs from Palos in Spain toward South America on a 7-month voyage to the New World. Niño sets sail in a small caravel with 33 men[8]
June 10 – Pope Alexander VI informs the Roman Catholic cardinals that the Sultan of the Ottoman Empire has amassed a fleet of 300 ships to lay siege to the city of Rhodes. [9]
June 15 – The Great Epidemic of plague reaches London, forcing King Henry and Queen Anne to flee to the capital to Langley on June 25 and then to Abingdon.[10]
June 20 – Queen Isabella of Spain orders Christopher Columbus to liberate and repatriate Indians from the New World, declaring that nobody had authorized him to kidnap any of her subjects.[11]
November 5 – The Catholicon is published in Tréguier (Brittany). This Breton–greek–Latin dictionary had been written in 1464 by Jehan Lagadeuc. It is the first dictionary of either French or Breton.
