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Dimethylcurcumin (development code ASC-J9) is a nonsteroidal antiandrogen and a synthetic curcuminoid.[1]

In vitro, it is an androgen receptor (AR) inhibitor and shows antiandrogenic activity, although its mechanism of action and effects differ from those of conventional antiandrogens; it is not an antagonist of the AR and instead appears to act as a selective degradation enhancer of certain subpopulations of the AR, for instance those present in the prostate gland.[1]

See also

References

  1. ^ a b Shi Q, Shih CC, Lee KH (2009). “Novel anti-prostate cancer curcumin analogues that enhance androgen receptor degradation activity”. Anticancer Agents Med Chem. 9 (8): 904–12. doi:10.2174/187152009789124655. PMID 19663790.