Autophagy-related protein 9A is a protein that in humans is encoded by the ATG9A gene.[5]
Functional studies indicate that ATG9A plays a role in autophagy.[6][7] and other non-autophagy membrane remodeling processes such as plasma membrane repair.[8] Enzymatically, it is a lipid scramblase.[6][7] ATG9A interacts with IQGAP1 and the ESCRT machinery in membrane remodeling.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000198925 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033124 – Ensembl, May 2017
- ^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ “Entrez Gene: ATG9A ATG9 autophagy related 9 homolog A (S. cerevisiae)”.
- ^ a b Maeda S, Yamamoto H, Kinch LN, Garza CM, Takahashi S, Otomo C, et al. (December 2020). “Structure, lipid scrambling activity and role in autophagosome formation of ATG9A”. Nature Structural & Molecular Biology. 27 (12): 1194–1201. doi:10.1038/s41594-020-00520-2. PMC 7718406. PMID 33106659.
- ^ a b Matoba K, Kotani T, Tsutsumi A, Tsuji T, Mori T, Noshiro D, et al. (December 2020). “Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion”. Nature Structural & Molecular Biology. 27 (12): 1185–1193. doi:10.1038/s41594-020-00518-w. PMID 33106658. S2CID 225081989.
- ^ a b Claude-Taupin A, Jia J, Bhujabal Z, Garfa-Traoré M, Kumar S, da Silva GP, et al. (July 2021). “ATG9A protects the plasma membrane from programmed and incidental permeabilization”. Nature Cell Biology. 23 (8): 846–858. doi:10.1038/s41556-021-00706-w. ISSN 1465-7392. PMC 8276549. PMID 34257406.
Further reading
- Hartley JL, Temple GF, Brasch MA (November 2000). “DNA cloning using in vitro site-specific recombination”. Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (March 2001). “Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs”. Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, et al. (September 2004). “Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions”. Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004). “From ORFeome to biology: a functional genomics pipeline”. Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Yamada T, Carson AR, Caniggia I, Umebayashi K, Yoshimori T, Nakabayashi K, Scherer SW (May 2005). “Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast”. The Journal of Biological Chemistry. 280 (18): 18283–90. doi:10.1074/jbc.M413957200. PMID 15755735.
- Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (January 2006). “The LIFEdb database in 2006”. Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
External links
- Human ATG9A genome location and ATG9A gene details page in the UCSC Genome Browser.