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Anhalamine is a naturally occurring tetrahydroisoquinoline alkaloid which can be isolated from Lophophora williamsii.[1] It is structurally related to mescaline.[2] It has been found to act as a potent inverse agonist of the serotonin 5-HT7 receptor.[3]

See also

References

  1. ^ Lundström, J; Agurell, S (August 1968). “Biosynthesis of mescaline and anhalamine in peyote. IIa”. Tetrahedron Letters. 9 (42): 4437–40. doi:10.1016/s0040-4039(01)99153-1. PMID 5672059.
  2. ^ Ghansah, E.; Kopsombut, P.; Maleque, M.A.; Brossi, A. (February 1993). “Effects of mescaline and some of its analogs on cholinergic neuromuscular transmission”. Neuropharmacology. 32 (2): 169–174. doi:10.1016/0028-3908(93)90097-M. PMID 8383816. S2CID 42388554.
  3. ^ Chan CB, Pottie E, Simon IA, Rossebø AG, Herth MM, Harpsøe K, Kristensen JL, Stove CP, Poulie CB (February 2025). “Synthesis, Pharmacological Characterization, and Binding Mode Analysis of 8-Hydroxy-Tetrahydroisoquinolines as 5-HT7 Receptor Inverse Agonists”. ACS Chem Neurosci. 16 (3): 439–451. doi:10.1021/acschemneuro.4c00667. hdl:1854/LU-01JQ6WFR8R7G85440FRY2248HG. PMID 39836645.