Animal models of epilepsy have helped to advance the understanding of how normal brains develop epilepsy (a process known as Epileptogenesis), and have been used in pre-clinical trials of antiepileptic drugs.[1] Epilepsy is a set of syndromes which have in common a predisposition to recurrent epileptic seizures.[2] Animal models of epilepsy and seizures can be divided into four basic categories: genetic animal models, chemically induced models, electrically induced models, and in more recent years infection-induced models.[3][4] New models are using light-gated ion channels to turn on cell firing and these are part of optogenetic induction models of epilepsy.[5]
References
- ^ Sarkisian, Matthew R. (31 May 2001). “Overview of the Current Animal Models for Human Seizure and Epileptic Disorders”. Epilepsy & Behavior. 2 (3): 201–216. doi:10.1006/ebeh.2001.0193. PMID 12609365.
- ^ Chang, Bernard S.; Lowenstein, Daniel H. (25 September 2003). “Epilepsy”. New England Journal of Medicine. 349 (13): 1257–1266. doi:10.1056/NEJMra022308. PMID 14507951.
- ^ Löscher, Wolfgang (31 May 2011). “Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs”. Seizure. 20 (5): 359–368. doi:10.1016/j.seizure.2011.01.003. PMID 21292505. Retrieved 1 August 2012.
- ^ Batot, Gaelle; Metcalf, Cameron S.; Bell, Laura A.; Pauletti, Alberto; Wilcox, Karen S.; Bröer, Sonja (2022-06-23). “A Model for Epilepsy of Infectious Etiology using Theiler’s Murine Encephalomyelitis Virus”. Journal of Visualized Experiments (184). doi:10.3791/63673. ISSN 1940-087X. PMC 11060116. PMID 35816000.
- ^ Cela, Elvis; McFarlan, Amanda R.; Chung, Andrew J.; Wang, Taiji; Chierzi, Sabrina; Murai, Keith K.; Sjöström, P. Jesper (March 27, 2019). “An Optogenetic Kindling Model of Neocortical Epilepsy”. Scientific Reports. 9 (1): 5236. doi:10.1038/s41598-019-41533-2. ISSN 2045-2322. PMC 6437216. PMID 30918286.