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Arachidonyl-2′-chloroethylamide (ACEA) is a synthetic agonist of the CB₁ (CB1R). ACEA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the CB₂ (CB2R) (K_i = 1.4 nM for CB1R; K_i = 3100 nM for CB2R).^[1]

References

^ Hillard, CJ; Manna, S; Greenberg, MJ; Dicamelli, R; Ross, RA; Stevenson, LA; Murphy, V; Pertwee, RG; Campbell, WB (1999). “Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1)”. The Journal of Pharmacology and Experimental Therapeutics. 289 (3): 1427–33. doi:10.1016/S0022-3565(24)38289-8. PMID 10336536.

[rdp-we-cite_note-1] Hillard, CJ; Manna, S; Greenberg, MJ; Dicamelli, R; Ross, RA; Stevenson, LA; Murphy, V; Pertwee, RG; Campbell, WB (1999). “Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1)”. The Journal of Pharmacology and Experimental Therapeutics. 289 (3): 1427–33. doi:10.1016/S0022-3565(24)38289-8. PMID 10336536.

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