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Bay K8644 is a chemical compound that functions as an L-type calcium channel agonist. Bay K8644 is used primarily as a biochemical research tool for this effect.^[2] It is a structural analog of nifedipine with positive inotropic activity, and as an aromatic it is highly lipid soluble.

Mechanism of action

Bay K8644 targets L-type voltage-gated calcium channels. It is the first positive inotropic agent shown to act specifically and directly on calcium channels.^[3]

References

^ (±)-Bay K8644 at Sigma-Aldrich
^ CID 2303 from PubChem
^ Thomas, G; Chung, M; Cohen, CJ (January 1985). “A dihydropyridine (Bay k 8644) that enhances calcium currents in guinea pig and calf myocardial cells. A new type of positive inotropic agent”. Circ Res. 56 (1): 87–96. doi:10.1161/01.res.56.1.87. PMID 2578336.

[rdp-we-cite_note-1] (±)-Bay K8644 at Sigma-Aldrich

[rdp-we-cite_note-2] CID 2303 from PubChem

[rdp-we-cite_note-3] Thomas, G; Chung, M; Cohen, CJ (January 1985). “A dihydropyridine (Bay k 8644) that enhances calcium currents in guinea pig and calf myocardial cells. A new type of positive inotropic agent”. Circ Res. 56 (1): 87–96. doi:10.1161/01.res.56.1.87. PMID 2578336.

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