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Catharanthalog (CAG) is a non-hallucinogenic serotonin receptor modulator of the ibogalog group related to the iboga alkaloid catharanthine but with a simplified chemical structure.[1][2] It is known to act as a serotonin 5-HT2A receptor partial agonist.[2] The drug produces analgesic-like effects in a neuropathic pain model in rodents that can be reduced by the serotonin 5-HT2A receptor antagonist ketanserin.[2] Catharanthalog is said to have relatively low blood–brain barrier permeability owing to relatively low lipophilicity.[2] It does not produce the head-twitch response, a behavioral proxy of psychedelic effects, in rodents.[2] The drug was first described in the scientific literature by 2025.[1][2]

See also

References

  1. ^ a b Czopek A, Jończyk J, Fryc M, Kluzik D, Zagórska A (June 2025). “Classic Psychedelics in Pain Modulation: Mechanisms, Clinical Evidence, and Future Perspectives”. ACS Chemical Neuroscience. 16 (12): 2163–2177. doi:10.1021/acschemneuro.5c00152. PMC 12183689. PMID 40474592. In an oxaliplatin-induced neuropathic pain model, catharanthalog (CAG), noribogainalog (nor-IBG), and another ibogalog derivative, PNU-22394 also demonstrated consistent analgesic efficacy without observable toxicity.
  2. ^ a b c d e f Arias HR, Micheli L, Jensen AA, Galant S, Vandermoere F, Venturi D, et al. (March 2025). “Ibogalogs decrease neuropathic pain in mice through a mechanism involving crosstalk between 5-HT2A and mGlu2 receptors” (PDF). Biomedicine & Pharmacotherapy. 184 117887. doi:10.1016/j.biopha.2025.117887. PMID 39938347.