Dexamethasone-BSA, also known as dexamethasone-bovine serum albumin conjugate, is a conjugate of the corticosteroid dexamethasone and the serum albumin bovine serum albumin (BSA).[1] It is a membrane-limited glucocorticoid that is unable to diffuse into cells and can dissociate rapid membrane-mediated glucocorticoid receptor effects from intracellular or genomic effects.[1] The drug is used in scientific research to study the actions of membrane glucocorticoid receptors.[1][2][3][4]
References
- ^ a b c Weiss GL, Rainville JR, Zhao Q, Tasker JG (February 2019). “Purity and stability of the membrane-limited glucocorticoid receptor agonist dexamethasone-BSA”. Steroids. 142: 2–5. doi:10.1016/j.steroids.2017.09.004. PMC 5860924. PMID 28939328.
- ^ Evanson NK, Tasker JG, Hill MN, Hillard CJ, Herman JP (October 2010). “Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling”. Endocrinology. 151 (10): 4811–4819. doi:10.1210/en.2010-0285. PMC 2946139. PMID 20702575.
- ^ Strehl C, Gaber T, Löwenberg M, Hommes DW, Verhaar AP, Schellmann S, et al. (December 2011). “Origin and functional activity of the membrane-bound glucocorticoid receptor”. Arthritis and Rheumatism. 63 (12): 3779–3788. doi:10.1002/art.30637. PMID 21898343.
- ^ Ma L, Wei J, Deng MY, Ahmad KA, Huang J, Zhao MJ, et al. (January 2026). “Spinal microglial membrane glucocorticoid receptors regulate anti-hypersensitivity by stimulating dynorphin A expression”. European Journal of Pharmacology. 1010 178362. doi:10.1016/j.ejphar.2025.178362. PMID 41276104.