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Dihydrothymine is an intermediate in the metabolism of thymine. The enzyme dihydrouracil dehydrogenase (NAD+) converts thymine to dihydrothymine in the reaction:[1][2]

2D representation of the chemical structure of thymine .
thymine
+ NADH
 
 
H+
 
Reversible left-right reaction arrow with minor forward substrate(s) from top left and minor reverse product(s) to bottom left
H+
 
 
2D representation of the chemical structure of dihydrothymine .
dihydrothymine
+ NAD+
 


References

  1. ^ Campbell LL (August 1957). “Reductive degradation of pyrimidines. III. Purification and properties of dihydrouracil dehydrogenase”. The Journal of Biological Chemistry. 227 (2): 693–700. doi:10.1016/S0021-9258(18)70749-7. PMID 13462991.
  2. ^ West, Thomas P. (2001). “Pyrimidine base catabolism in Pseudomonas putida biotype B”. Antonie van Leeuwenhoek. 80 (2): 163–167. doi:10.1023/A:1012275512136. PMID 11759049.