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N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) is a dopamine-receptor antagonist.[2]

EEDQ is also a highly specific reagent for carboxyl groups. It enables the coupling of acylamino acids with amino acid esters in high yield and without racemization.[3]

It is also an irreversible dopamine transporter (DAT) blocker in vitro, though it is ineffective in vivo.[4]

References

  1. ^ 2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline at Sigma-Aldrich
  2. ^ Neuroscience Letters 1992, 137(2), p.265
  3. ^ https://www.bachem.com/
  4. ^ Tarazi FI, Kula NS, Zhang K, Baldessarini RJ (August 2000). “Alkylation of rat dopamine transporters and blockade of dopamine uptake by EEDQ”. Neuropharmacology. 39 (11): 2133–8. doi:10.1016/s0028-3908(00)00047-2. PMID 10963756.