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2-Ethyl-5-methoxy-N,N-dimethyltryptamine (EMDT), also known as 2-ethyl-5-MeO-DMT, is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT6 receptor agonist, with a Ki of 16 nM, and was one of the first selective agonists developed for this receptor.[1][2] Its affinities for many other targets have also been reported.[2] EMDT inhibits both short- and long-term memory formation in animal studies, and this effect can be reversed by the selective 5-HT6 antagonist SB-399,885.[3] Additionally, it is active in the tail suspension test, suggesting that it could be an effective antidepressant.[4]

See also

References

  1. ^ Glennon RA, Lee M, Rangisetty JB, Dukat M, Roth BL, Savage JE, et al. (March 2000). “2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors”. Journal of Medicinal Chemistry. 43 (5): 1011–1018. doi:10.1021/jm990550b. PMID 10715164.
  2. ^ a b Ray TS (February 2010). “Psychedelics and the human receptorome”. PLOS ONE. 5 (2) e9019. Bibcode:2010PLoSO…5.9019R. doi:10.1371/journal.pone.0009019. PMC 2814854. PMID 20126400.
  3. ^ Meneses A, Perez-Garcia G, Liy-Salmeron G, Flores-Galvez D, Castillo C, Castillo E (December 2008). “The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation”. Behavioural Brain Research. 195 (1): 112–119. doi:10.1016/j.bbr.2007.11.023. PMID 18191236. S2CID 144901859.
  4. ^ Svenningsson P, Tzavara ET, Qi H, Carruthers R, Witkin JM, Nomikos GG, Greengard P (April 2007). “Biochemical and behavioral evidence for antidepressant-like effects of 5-HT6 receptor stimulation”. The Journal of Neuroscience. 27 (15): 4201–4209. doi:10.1523/JNEUROSCI.3110-06.2007. PMC 6672541. PMID 17428998.