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For the American baseball player, see Evan Reed.
Professor Evan Reid

Evan Reid is a Scottish neurogenetics researcher and clinical academic. He is Professor of Neurogenetics and Molecular Neurobiology at the University of Cambridge and a principal investigator at the Cambridge Institute for Medical Research.[1] His research focuses on the clinical features, genetics, and molecular cell biology of hereditary spastic paraplegias (HSPs).[2][3][4]

Career & research

Reid’s lab has identified mulitiple genetic loci and causitive genes for neurological conditions. In 2012, his research identified abnormalities in the Reticulon 2 gene as a cause of hereditary spastic paraplegia.[5][6] He also reported several other causative genes, including KIF5A (responsible for HSP type 10). This work has been highlighted by patient advocacy groups as a key advancement in understanding the condition.[7][8]

His work has specifically examined the cellular functions of spastin, the protein most frequently mutated in HSP. This research has elucidated spastin’s role in cell division and endosomal trafficking, providing insights into the mechanisms of axonal degeneration.[9]

Reid and colleagues also reported that mutations in the VPS4A gene cause a previously undescribed neurodevelopmental condition, which they termed CIMDAG.[10][11][12]

Professional recognition

Reid is a Fellow of the Royal College of Physicians and Surgeons of Glasgow (2004).[13] He was elected a Fellow of St Edmund’s College, Cambridge, in 2010, and appointed Lecturer at the University of Cambridge in 2014.[14][15][16] He has held both an Advanced Research Fellowship (2004) and a Senior Research Fellowship (2008) from the Wellcome Trust.[17]

Reid serves on the medical board of The Maddi Foundation, an independent charity supporting research into rare neurodegenerative diseases.[18]

References

  1. ^ Reid, Evan (2020-09-03). “Professor Evan Reid”. www.cimr.cam.ac.uk. Retrieved 2026-03-19.
  2. ^ Reid, E. (November 1999). “The hereditary spastic paraplegias”. Journal of Neurology. 246 (11): 995–1003. doi:10.1007/s004150050503. ISSN 0340-5354. PMID 10631629.
  3. ^ Blackstone, Craig; O’Kane, Cahir J.; Reid, Evan (January 2011). “Hereditary spastic paraplegias: membrane traffic and the motor pathway”. Nature Reviews Neuroscience. 12 (1): 31–42. doi:10.1038/nrn2946. ISSN 1471-0048.
  4. ^ Shribman, Samuel; Reid, Evan; Crosby, Andrew H.; Houlden, Henry; Warner, Thomas T. (2019-12-01). “Hereditary spastic paraplegia: from diagnosis to emerging therapeutic approaches”. The Lancet Neurology. 18 (12): 1136–1146. doi:10.1016/S1474-4422(19)30235-2. ISSN 1474-4422. PMID 31377012.
  5. ^ “Spasticity gene finding provides clues to causes of nerve cell degeneration”. Wellcome. 2012-01-10. Retrieved 2026-03-19.
  6. ^ “Spasticity gene finding provides clues to causes of nerve cell degeneration”. ScienceDaily. Retrieved 2026-03-19.
  7. ^ “Articles/Papers/Studies : HSP : HSP & PLS : Spastic Paraplegia Foundation”. sp-foundation.org. Retrieved 2026-03-19.
  8. ^ Reid, Evan; Kloos, Mark; Ashley-Koch, Allison; Hughes, Lori; Bevan, Simon; Svenson, Ingrid K.; Graham, Felicia Lennon; Gaskell, Perry C.; Dearlove, Andrew; Pericak-Vance, Margaret A.; Rubinsztein, David C.; Marchuk, Douglas A. (November 2002). “A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10)”. American Journal of Human Genetics. 71 (5): 1189–1194. doi:10.1086/344210. ISSN 0002-9297. PMC 385095. PMID 12355402.
  9. ^ Allison, Rachel; Lumb, Jennifer H.; Fassier, Coralie; Connell, James W.; Ten Martin, Daniel; Seaman, Matthew N. J.; Hazan, Jamilé; Reid, Evan (2013-08-05). “An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome”. The Journal of Cell Biology. 202 (3): 527–543. doi:10.1083/jcb.201211045. ISSN 1540-8140. PMC 3734076. PMID 23897888.
  10. ^ Rodger, Catherine; Flex, Elisabetta; Allison, Rachel J.; Sanchis-Juan, Alba; Hasenahuer, Marcia A.; Cecchetti, Serena; French, Courtney E.; Edgar, James R.; Carpentieri, Giovanna; Ciolfi, Andrea; Pantaleoni, Francesca; Bruselles, Alessandro; Onesimo, Roberta; Zampino, Giuseppe; Marcon, Francesca (December 2020). “De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment”. The American Journal of Human Genetics. 107 (6): 1129–1148. doi:10.1016/j.ajhg.2020.10.012. ISSN 0002-9297. PMC 7820634. PMID 33186545.
  11. ^ “Entry – *609982 – VACUOLAR PROTEIN SORTING 4 HOMOLOG A; VPS4A – OMIM – (OMIM.ORG)”. omim.org. Retrieved 2026-03-19.
  12. ^ “Entry – #619273 – CIMDAG SYNDROME; CIMDAG – OMIM – (OMIM.ORG)”. omim.org. Retrieved 2026-03-19.
  13. ^ “Professor Evan Reid”. Cambridge University Hospitals. Retrieved 2026-03-19.
  14. ^ “Professor Evan Reid”. St Edmund’s College. Retrieved 2026-03-19.
  15. ^ “College Notices – Cambridge University Reporter 6197”. www.admin.cam.ac.uk. Retrieved 2026-03-19.
  16. ^ “Vacancies, appointments, etc. – Cambridge University Reporter 6355”. www.admin.cam.ac.uk. Retrieved 2026-03-19.
  17. ^ “Funding portfolio | Research funding”. Wellcome. 2020-09-18. Retrieved 2026-03-19.
  18. ^ “The Maddie Foundation: The Medica Board”.{{cite web}}: CS1 maint: url-status (link)