Fibulin-2 is a protein that in humans is encoded by the FBLN2 gene.[5][6]
This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal structures. Alternatively spliced transcript variants encoding different isoforms have been identified.[6]
Its role as a biomarker for meningiomas (a common tumour affecting the central nervous system) was recently described where a blood test can predict whether patients have a grade II meningiomas (poor outcome) and not a grade I meningioma (better outcome), without the need for a surgical biopsy.[7]
Interactions
FBLN2 has been shown to interact with Laminin, alpha 1,[8][9] Laminin, alpha 5[8] and Perlecan.[10][11]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000163520 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064080 – Ensembl, May 2017
- ^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Zhang RZ, Pan TC, Zhang ZY, Mattei MG, Timpl R, Chu ML (January 1995). “Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and mapping of the gene on human and mouse chromosomes”. Genomics. 22 (2): 425–430. doi:10.1006/geno.1994.1404. PMID 7806230.
- ^ a b EntrezGene 2199 “FBLN2 fibulin 2 [ Homo sapiens (human) ]”
- ^ Sofela AA, Hilton DA, Ammoun S, Baiz D, Adams CL, Ercolano E, et al. (January 2021). “Fibulin-2: A Novel Biomarker for Differentiating Grade II from Grade I Meningiomas”. International Journal of Molecular Sciences. 22 (2): 560. doi:10.3390/ijms22020560. PMC 7827565. PMID 33429944.
- ^ a b Utani A, Nomizu M, Yamada Y (January 1997). “Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences”. The Journal of Biological Chemistry. 272 (5): 2814–2820. doi:10.1074/jbc.272.5.2814. PMID 9006922.
- ^ Talts JF, Sasaki T, Miosge N, Göhring W, Mann K, Mayne R, et al. (November 2000). “Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues”. The Journal of Biological Chemistry. 275 (45): 35192–35199. doi:10.1074/jbc.M003261200. PMID 10934193.
- ^ Hopf M, Göhring W, Mann K, Timpl R (August 2001). “Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan”. Journal of Molecular Biology. 311 (3): 529–541. doi:10.1006/jmbi.2001.4878. PMID 11493006.
- ^ Sasaki T, Göhring W, Pan TC, Chu ML, Timpl R (December 1995). “Binding of mouse and human fibulin-2 to extracellular matrix ligands”. Journal of Molecular Biology. 254 (5): 892–899. doi:10.1006/jmbi.1995.0664. PMID 7500359.
Further reading
- Pan TC, Sasaki T, Zhang RZ, Fässler R, Timpl R, Chu ML (December 1993). “Structure and expression of fibulin-2, a novel extracellular matrix protein with multiple EGF-like repeats and consensus motifs for calcium binding”. The Journal of Cell Biology. 123 (5): 1269–1277. doi:10.1083/jcb.123.5.1269. PMC 2119879. PMID 8245130.
- Reinhardt DP, Sasaki T, Dzamba BJ, Keene DR, Chu ML, Göhring W, et al. (August 1996). “Fibrillin-1 and fibulin-2 interact and are colocalized in some tissues”. The Journal of Biological Chemistry. 271 (32): 19489–19496. doi:10.1074/jbc.271.32.19489. PMID 8702639.
- Miosge N, Götz W, Sasaki T, Chu ML, Timpl R, Herken R (February 1996). “The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryo”. The Histochemical Journal. 28 (2): 109–116. doi:10.1007/BF02331415. PMID 8737292. S2CID 25996538.
- Collod G, Chu ML, Sasaki T, Coulon M, Timpl R, Renkart L, et al. (1996). “Fibulin-2: genetic mapping and exclusion as a candidate gene in Marfan syndrome type 2”. European Journal of Human Genetics. 4 (5): 292–295. doi:10.1159/000472216. PMID 8946175. S2CID 9891855.
- Sasaki T, Mann K, Wiedemann H, Göhring W, Lustig A, Engel J, et al. (June 1997). “Dimer model for the microfibrillar protein fibulin-2 and identification of the connecting disulfide bridge”. The EMBO Journal. 16 (11): 3035–3043. doi:10.1093/emboj/16.11.3035. PMC 1169922. PMID 9214621.
- Brown JC, Sasaki T, Göhring W, Yamada Y, Timpl R (November 1997). “The C-terminal domain V of perlecan promotes beta1 integrin-mediated cell adhesion, binds heparin, nidogen and fibulin-2 and can be modified by glycosaminoglycans”. European Journal of Biochemistry. 250 (1): 39–46. doi:10.1111/j.1432-1033.1997.t01-1-00039.x. PMID 9431988.
- Raghunath M, Tschödrich-Rotter M, Sasaki T, Meuli M, Chu ML, Timpl R (January 1999). “Confocal laser scanning analysis of the association of fibulin-2 with fibrillin-1 and fibronectin define different stages of skin regeneration”. The Journal of Investigative Dermatology. 112 (1): 97–101. doi:10.1046/j.1523-1747.1999.00483.x. PMID 9886271.
- Kuivaniemi H, Marshall A, Ganguly A, Chu ML, Abbott WM, Tromp G (1998). “Fibulin-2 exhibits high degree of variability, but no structural changes concordant with abdominal aortic aneurysms”. European Journal of Human Genetics. 6 (6): 642–646. doi:10.1038/sj.ejhg.5200245. PMID 9887386.
- Sasaki T, Göhring W, Miosge N, Abrams WR, Rosenbloom J, Timpl R (October 1999). “Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins”. FEBS Letters. 460 (2): 280–284. doi:10.1016/S0014-5793(99)01362-9. PMID 10544250. S2CID 25139630.
- Gu YC, Nilsson K, Eng H, Ekblom M (2000). “Association of extracellular matrix proteins fibulin-1 and fibulin-2 with fibronectin in bone marrow stroma”. British Journal of Haematology. 109 (2): 305–313. doi:10.1046/j.1365-2141.2000.02011.x. PMID 10848816. S2CID 37405859.
- Olin AI, Mörgelin M, Sasaki T, Timpl R, Heinegård D, Aspberg A (January 2001). “The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding”. The Journal of Biological Chemistry. 276 (2): 1253–1261. doi:10.1074/jbc.M006783200. PMID 11038354.
- Hunzelmann N, Nischt R, Brenneisen P, Eickert A, Krieg T (August 2001). “Increased deposition of fibulin-2 in solar elastosis and its colocalization with elastic fibres”. The British Journal of Dermatology. 145 (2): 217–222. doi:10.1046/j.1365-2133.2001.04337.x. PMID 11531782. S2CID 45863539.
- Sasaki T, Göhring W, Mann K, Brakebusch C, Yamada Y, Fässler R, et al. (December 2001). “Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins”. Journal of Molecular Biology. 314 (4): 751–763. doi:10.1006/jmbi.2001.5176. PMID 11733994.
- Bengtsson E, Mörgelin M, Sasaki T, Timpl R, Heinegård D, Aspberg A (April 2002). “The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor”. The Journal of Biological Chemistry. 277 (17): 15061–15068. doi:10.1074/jbc.M108285200. PMID 11847210.