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FPPQ is an experimental drug related to quipazine, which acts as a selective antagonist of both the 5-HT3 and 5-HT6 serotonin receptors. It has antipsychotic and memory-enhancing effects in animal studies.[1][2]

References

  1. ^ Zajdel P, Grychowska K, Mogilski S, Kurczab R, Satała G, Bugno R, et al. (September 2021). “Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT3 and 5-HT6 Receptor Antagonist with Antipsychotic and Procognitive Properties”. Journal of Medicinal Chemistry. 64 (18): 13279–13298. doi:10.1021/acs.jmedchem.1c00224. PMC 8474115. PMID 34467765.
  2. ^ Castañé A, Cano M, Ruiz-Avila L, Miquel-Rio L, Celada P, Artigas F, et al. (May 2022). “Dual 5-HT3 and 5-HT6 Receptor Antagonist FPPQ Normalizes Phencyclidine-Induced Disruption of Brain Oscillatory Activity in Rats”. The International Journal of Neuropsychopharmacology. 25 (5): 425–431. doi:10.1093/ijnp/pyac003. PMC 9154270. PMID 35022720.