Histamine trifluoromethyl toluidide (HTFMT) is a mixed H1/H2 histamine agonist which is significantly more potent than histamine itself.[1]
It also produces additional actions which appear to be independent of histamine receptors.[2][3]
References
- ^ Whyment, AD; Blanks, AM; Lee, K; Renaud, LP; Spanswick, D (Apr 2006). “Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors”. Journal of Neurophysiology. 95 (4): 2492–500. doi:10.1152/jn.01135.2004. PMID 16354729.
- ^ Qiu, R; Melmon, KL; Khan, MM (Jun 1990). “Effects of histamine-trifluoromethyl-toluidide derivative (HTMT) on intracellular calcium in human lymphocytes”. Journal of Pharmacology and Experimental Therapeutics. 253 (3): 1245–52. doi:10.1016/S0022-3565(25)13228-X. PMID 2359026.
- ^ Kim, DC; Lee, SY; Jun, DJ; Kim, SH; Lee, JH; Hur, EM; Baek, NI; Kim, KT (Nov 2005). “Inhibition of store-operated calcium entry-mediated superoxide generation by histamine trifluoromethyltoluide independent of histamine receptors”. Biochemical Pharmacology. 70 (11): 1613–22. doi:10.1016/j.bcp.2005.09.001. PMID 16219299.