Intercellular adhesion molecule 5 is a protein that in humans is encoded by the ICAM5 gene.[5][6][7]
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.[7]
Studies mentioned a role for ICAM5 in cell adhesion and cell signalling and dysregulation and disfunction of it will increase the risk of breast cancer.[8] Study of the association between polymorphisms and breast cancer has been shown that ICAM5 rs1056538 and ICAM5 rs281439 variants might contribute the most in the development of breast cancer.[9]
Interactions
ICAM5 has been shown to interact with PSEN1.[10]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000105376 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032174 – Ensembl, May 2017
- ^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mizuno T, Yoshihara Y, Inazawa J, Kagamiyama H, Mori K (February 1997). “cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1”. The Journal of Biological Chemistry. 272 (2): 1156–1163. doi:10.1074/jbc.272.2.1156. PMID 8995416.
- ^ Kilgannon P, Turner T, Meyer J, Wisdom W, Gallatin WM (January 1999). “Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2”. Genomics. 54 (2): 328–330. doi:10.1006/geno.1998.5565. PMID 9828136.
- ^ a b “Entrez Gene: ICAM5 intercellular adhesion molecule 5, telencephalin”.
- ^ Kammerer S, Roth RB, Reneland R, Marnellos G, Hoyal CR, Markward NJ, et al. (December 2004). “Large-scale association study identifies ICAM gene region as breast and prostate cancer susceptibility locus”. Cancer Research. 64 (24): 8906–8910. doi:10.1158/0008-5472.CAN-04-1788. PMID 15604251.
- ^ Liu L, Sun M, Song D, Wang Z (February 2013). “The genetic polymorphisms of intercellular cell adhesion molecules and breast cancer susceptibility: a meta-analysis”. Molecular Biology Reports. 40 (2): 1855–1860. doi:10.1007/s11033-012-2241-4. PMID 23079714.
- ^ Annaert WG, Esselens C, Baert V, Boeve C, Snellings G, Cupers P, et al. (November 2001). “Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins”. Neuron. 32 (4): 579–589. doi:10.1016/S0896-6273(01)00512-8. PMID 11719200. S2CID 2096602.
Further reading
- Yoshihara Y, Mori K (1995). “Telencephalin: a neuronal area code molecule?”. Neuroscience Research. 21 (2): 119–124. doi:10.1016/0168-0102(94)90153-8. PMID 7724062. S2CID 19931440.
- Hayflick JS, Kilgannon P, Gallatin WM (1998). “The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions”. Immunologic Research. 17 (3): 313–327. doi:10.1007/BF02786454. PMID 9638475. S2CID 19901365.
- Benson DL, Yoshihara Y, Mori K (1998). “Polarized distribution and cell type-specific localization of telencephalin, an intercellular adhesion molecule”. Journal of Neuroscience Research. 52 (1): 43–53. doi:10.1002/(SICI)1097-4547(19980401)52:1<43::AID-JNR5>3.0.CO;2-K. PMID 9556028. S2CID 22675478.
- Rieckmann P, Turner T, Kligannon P, Steinhoff BJ (1998). “Telencephalin as an indicator for temporal-lobe dysfunction”. Lancet. 352 (9125): 370–371. doi:10.1016/S0140-6736(05)60469-2. PMID 9717930. S2CID 6255738.
- Arii N, Mizuguchi M, Mori K, Takashima S (1999). “Development of telencephalin in the human cerebrum”. Microscopy Research and Technique. 46 (1): 18–23. doi:10.1002/(SICI)1097-0029(19990701)46:1<18::AID-JEMT2>3.0.CO;2-G. PMID 10402269. S2CID 22133468.
- Mizuno T, Yoshihara Y, Kagamiyama H, Ohsawa K, Imai Y, Kohsaka S, et al. (December 1999). “Neuronal adhesion molecule telencephalin induces rapid cell spreading of microglia”. Brain Research. 849 (1–2): 58–66. doi:10.1016/S0006-8993(99)01984-8. PMID 10592287. S2CID 353053.
- Tian L, Kilgannon P, Yoshihara Y, Mori K, Gallatin WM, Carpén O, et al. (March 2000). “Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18”. European Journal of Immunology. 30 (3): 810–818. doi:10.1002/1521-4141(200003)30:3<810::AID-IMMU810>3.0.CO;2-X. PMID 10741396.
- Tian L, Nyman H, Kilgannon P, Yoshihara Y, Mori K, Andersson LC, et al. (July 2000). “Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion”. The Journal of Cell Biology. 150 (1): 243–252. doi:10.1083/jcb.150.1.243. PMC 2185561. PMID 10893271.
- Annaert WG, Esselens C, Baert V, Boeve C, Snellings G, Cupers P, et al. (November 2001). “Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins”. Neuron. 32 (4): 579–589. doi:10.1016/S0896-6273(01)00512-8. PMID 11719200. S2CID 2096602.
- Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, et al. (May 2003). “Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides”. Nature Biotechnology. 21 (5): 566–569. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
- Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). “Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry”. Analytical Chemistry. 76 (10): 2763–2772. Bibcode:2004AnaCh..76.2763B. doi:10.1021/ac035352d. PMID 15144186.
- Cox DG, Hankinson SE, Hunter DJ (2006). “Polymorphisms in the ICAM gene locus are not associated with breast cancer Risk”. Cancer Epidemiology, Biomarkers & Prevention. 15 (1): 178–179. doi:10.1158/1055-9965.EPI-05-0790. PMID 16434609.