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Indolin-2-one monooxygenase (EC 1.14.14.157, BX3 (gene), CYP71C2 (gene)) is an enzyme with systematic name indolin-2-one,NAD(P)H:oxygen oxidoreductase (3-hydroxylating).[1] It catalyses the following chemical reaction:

2D representation of the chemical structure of oxindole .
oxindole
 
O2
H2O
Rightward reaction arrow with minor substrate(s) from top left and minor product(s) to top right
 
 
 
2D representation of the chemical structure of Q27103761.
3-hydroxyindolin-2-one


Indolin-2-one monooxygenase is a cytochrome P450 protein containing heme, isolated from Poaceae (grasses). It uses molecular oxygen for the oxidation and requires a partner cytochrome P450 reductase for functional expression. This uses nicotinamide adenine dinucleotide phosphate. It is involved in the biosynthesis of protective and allelopathic benzoxazinoids in some plants.[2][3]

References

  1. ^ Frey M, Chomet P, Glawischnig E, Stettner C, Grün S, Winklmair A, Eisenreich W, Bacher A, Meeley RB, Briggs SP, Simcox K, Gierl A (August 1997). “Analysis of a chemical plant defense mechanism in grasses”. Science. 277 (5326): 696–9. doi:10.1126/science.277.5326.696. PMID 9235894.
  2. ^ Enzyme 1.14.14.157 at KEGG Pathway Database.
  3. ^ Glawischnig E, Grün S, Frey M, Gierl A (March 1999). “Cytochrome P450 monooxygenases of DIBOA biosynthesis: specificity and conservation among grasses”. Phytochemistry. 50 (6): 925–30. Bibcode:1999PChem..50..925G. doi:10.1016/s0031-9422(98)00318-5. PMID 10385992.