MRS7292 is an experimental drug that selectively activates the adenosine A3 receptor with moderate affinity and also inhibits a dopamine reuptake. This combination of mechanisms has been observed in the same molecule.[1][2]
See also
References
- ^ Tosh DK, Janowsky A, Eshleman AJ, Warnick E, Gao ZG, Chen Z, et al. (April 2017). “Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters”. Journal of Medicinal Chemistry. 60 (7): 3109–3123. doi:10.1021/acs.jmedchem.7b00141. PMC 5501184. PMID 28319392.
- ^ Tosh DK, Salmaso V, Rao H, Campbell R, Bitant A, Gao ZG, et al. (October 2020). “Direct Comparison of (N)-Methanocarba and Ribose-Containing 2-Arylalkynyladenosine Derivatives as A3 Receptor Agonists”. ACS Medicinal Chemistry Letters. 11 (10): 1935–1941. doi:10.1021/acsmedchemlett.9b00637. PMC 7549272. PMID 33062176.