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Miotine is an anticholinesterase drug. Miotine was the first synthetic carbamate that was used clinically.[2]

Unlike the miotine analog neostigmine, it doesn’t have a quaternary ammonium group to give it a permanent positive charge. It can exist as an uncharged free base which could allow it to cross the blood–brain barrier and cause unwanted central nervous system (CNS) side effects.[3]

Miotine equilibrium
Miotine equilibrium

See also

References

  1. ^ a b Chemical Warfare Agents, and Related Chemical Problems. Parts I-II. 1958.
  2. ^ “Archived copy” (PDF). Archived from the original (PDF) on 2009-05-09. Retrieved 2008-01-04.{{cite web}}: CS1 maint: archived copy as title (link)
  3. ^ “An introduction to drugs, their action and discovery” (PDF).