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Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the central nervous system.[1] It has been found to trigger dopamine release in the nucleus accumbens of rats.[2]

Derivatives

See also

References

  1. ^ Higgins GA, Joharchi N, Sellers EM (March 1993). “Behavioral effects of the 5-hydroxytryptamine3 receptor agonists 1-phenylbiguanide and m-chlorophenylbiguanide in rats”. The Journal of Pharmacology and Experimental Therapeutics. 264 (3). Journal of Pharmacology and Experimental Therapeutics: 1440–9. PMID 8450478.
  2. ^ Chen JP, van Praag HM, Gardner EL (March 1991). “Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens”. Brain Research. 543 (2). Brain Research.: 354–7. doi:10.1016/0006-8993(91)90050-6. PMID 1711914. S2CID 37426395.
  3. ^ Clauder Otto Dr Dipl Ing Chem; Zemplen Bela Dr; Bulcsu Gyula, AT168063 (1951 to Gedeon Richter), C.A. 47, 8097h (1953).
  4. ^ Overberger, C. G.; Shapiro, Seymour L. (1954). “Monomer Synthesis.1Triazines. The Reaction of Phenylbiguanide with Ethyl Oxalate and Ethyl Formate”. Journal of the American Chemical Society. 76 (1): 93–96. doi:10.1021/ja01630a025.
  5. ^ DE2130303 idem J Anatol, H Vidalenc, G Loiseau, US3769406 (1973 to Ugine Kuhlmann).