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Pimethixene is an antihistamine and anticholinergic of the thioxanthene chemical class originally developed to treat hyperactivity,[1] anxiety, sleep disorders, and allergy. It is also used for anesthesia and as a bronchodilator (to dilate the bronchi and bronchioles for more airflow).

In combination with pholcodine, it was sold in France by Laboratoires Salvoxyl in the 1970s as the antitussive Salvodex.[2] Pimethixene alone is still available in Brazil under the trade name Muricalm.

In addition to its other activities, it is a highly potent but non-selective serotonin 5-HT2B receptor antagonist.[3] The selective serotonin 5-HT2B receptor antagonist BF-1 was derived from pimethixene.[3]

See also

References

  1. ^ Chefneux A (July 1978). “[New treatment of hyperkinesis in the child: pimethixene]”. Revue Médicale de Liège. 33 (14): 500–3. PMID 674966.
  2. ^ Bailly, Christian (8 December 2020). “Salvodex® (9-(1-methyl, 4-piperylidenyl)thiaxanthene and pholcodine), from Laboratoires Salvoxyl (Orléans), 1971”. Oncowitan. Retrieved 4 January 2022.
  3. ^ a b Schmitz B, Ullmer C, Segelcke D, Gwarek M, Zhu XR, Lübbert H (March 2015). “BF-1–a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs”. Eur J Pharmacol. 751: 73–80. doi:10.1016/j.ejphar.2015.01.043. PMID 25666387.