Pirprofen was a nonsteroidal anti-inflammatory drug (NSAID)[1] that was brought to market by Ciba-Geigy in 1982 as a treatment for arthritis and pain. Its label was restricted after adverse events arose, including some cases of fatal liver toxicity.[2] Ciba-Geigy voluntarily withdrew the drug from the market worldwide in 1990.[3]: 223
References
- ^ Todd PA, Beresford R (December 1986). “Pirprofen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy”. Drugs. 32 (6): 509–37. doi:10.2165/00003495-198632060-00003. PMID 3539573. S2CID 195692709.
- ^ Depla AC, Vermeersch PH, van Gorp LH, Nadorp JH (August 1990). “Fatal acute liver failure associated with pirprofen. Report of a case and a review of the literature”. The Netherlands Journal of Medicine. 37 (1–2): 32–6. PMID 2215831.
- ^ WHO. Consolidated List of Products – Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or Not Approved by Governments, Twelfth Issue – Pharmaceuticals. United Nations – New York, 2005
| pyrazolones / pyrazolidines | |
|---|---|
| salicylates | |
| acetic acid derivatives and related substances | |
| oxicams | |
| propionic acid derivatives (profens) |
|
| n-arylanthranilic acids (fenamates) | |
| COX-2 inhibitors (coxibs) | |
| other | |
| NSAID combinations | |
Key: underline indicates initially developed first-in-class compound of specific group; #WHO-Essential Medicines; †withdrawn drugs; ‡veterinary use. | |
