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Prolintane is a central nervous system (CNS) stimulant[2] and norepinephrine–dopamine reuptake inhibitor (NDRI) of the phenylalkylpyrrolidine family developed in the 1950s.[3] Being an amphetamine derivative, it is closely related in chemical structure to other drugs such as pyrovalerone, MDPV, and propylhexedrine, and has a similar mechanism of action.[4] Many cases of prolintane abuse have been reported.[5]

Under the brand name Katovit, prolintane was commercialized by the Spanish pharmaceutical company FHER until 2001. It was most often used by students and workers as a stimulant to provide energy and increase alertness and concentration.[6] Prolintane and substituted prolintane analogs (fluoro and methyl) show DAT and NET inhibition in the low nanomolar range, which is consistent with NDRI psychostimulants such a methylphenidate.[6] In addition 4-substituted analogs have SERT inhibition which correlates with amphetamine SAR such as fenfluramine.[6]

See also

References

  1. ^ Anvisa (2023-03-31). “RDC Nº 784 – Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial” [Collegiate Board Resolution No. 784 – Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ Hollister LE, Gillespie HK (March–April 1970). “A new stimulant, prolintane hydrochloride, compared with dextroamphetamine in fatigued volunteers”. The Journal of Clinical Pharmacology and the Journal of New Drugs. 10 (2): 103–109. doi:10.1177/009127007001000205. PMID 4392006.
  3. ^ GB 807835, ”New tertiary amines and their salts and process for their preparation”, published 1959-01-21, assigned to Dr Karl Thomae GmbH and Boehringer Ingelheim Pharma GmbH and Co KG 
  4. ^ Nicholson AN, Stone BM, Jones MM (November 1980). “Wakefullness and reduced rapid eye movement sleep: studies with prolintane and pemoline”. British Journal of Clinical Pharmacology. 10 (5): 465–472. doi:10.1111/j.1365-2125.1980.tb01790.x. PMC 1430138. PMID 7437258.
  5. ^ Kyle PB, Daley WP (September 2007). “Domestic abuse of the European rave drug prolintane”. Journal of Analytical Toxicology. 31 (7): 415–418. doi:10.1093/jat/31.7.415. PMID 17725890.
  6. ^ a b c Kastner N, Islam MN, Dybek M, Roth E, Heisinger S, Holy M, et al. (December 2025). “Prolintane analogs as hybrid monoamine transporter ligands: Structural determinants and species differences”. The Journal of Biological Chemistry. 301 (12) 110903. doi:10.1016/j.jbc.2025.110903. PMC 12720098. PMID 41197716.