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Pyrinuron (Pyriminil, Vacor) is a chemical compound formerly used as a rodenticide.[1] Commercial distribution was voluntarily suspended in 1979 and it is not approved by the Environmental Protection Agency for use in the United States.[2] If it is ingested by humans in high doses, it may selectively destroy insulin-producing beta cells in the pancreas causing type 1 diabetes.[2] The neurodegeneration associated with Vacor is caused by its conversion to Vacor-mononucleotide (VMN) by NAMPT and VMN’s subsequent activation of the NADase SARM1.[3]

References

  1. ^ Vogel, R. P. (1982). “Poisoning with Vacor Rodenticide”. Archives of Pathology and Laboratory Medicine. 106 (3): 153. PMID 6895844.
  2. ^ a b “Pyriminil”. U.S. National Library of Medicine. Archived from the original on 2013-07-04. Retrieved 2013-11-04.
  3. ^ Loreto, Andrea; Angeletti, Carlo; Gu, Weixi; Osborne, Andrew; Nieuwenhuis, Bart; Gilley, Jonathan; Arthur-Farraj, Peter; Merlini, Elisa; Amici, Adolfo; Luo, Zhenyao; Hartley-Tassell, Lauren (2021). “Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1”. eLife. 10 e72823. bioRxiv 10.1101/2020.09.18.304261. doi:10.7554/eLife.72823. PMC 8758145. PMID 34870595.