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O-Glutarylpsilocin (developmental code name RE109), also known as 4-glutaryloxy-N,N-dimethyltryptamine (4-HO-DMT O-glutarate or 4-GO-DMT) is a serotonergic psychedelic of the tryptamine family.[1][2] It acts as a prodrug of psilocin (4-HO-DMT) similarly to other psilocin prodrugs like 4-AcO-DMT, 4-PrO-DMT, and psilocybin (4-PO-DMT).[1][2] The drug is cleaved into psilocin by non-specific esterases.[1][2] O-Glutarylpsilocin was first described in the scientific literature in 2024.[1][2] It has been patented by Reunion Neuroscience.[2] A related drug, luvesilocin (RE-104, FT-104; 4-GO-DiPT), a prodrug of 4-HO-DiPT, is being developed for potential medical use.[1][2]

Use and effects

See also: Psilocin § Uses, Psilocin § Effects, Psilocybin § Uses, and Psilocybin § Effects

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

See also

References

  1. ^ a b c d e Bryson N, Alexander R, Asnis-Alibozek A, Ehlers MD (June 2024). “RE104: Synthesis and Activity of a Novel Serotonergic Psychedelic Prodrug of 4-Hydroxy-N,N-diisopropyltryptamine”. ACS Chem Neurosci. 15 (12): 2386–2395. doi:10.1021/acschemneuro.4c00058. PMC 11191588. PMID 38758589.
  2. ^ a b c d e f “Improved pharmacokinetics of tryptamine prodrugs”. Google Patents. 4 January 2024. Retrieved 1 April 2025.