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SePP is a compound derived from the dissociative anesthetic diphenidine but containing an unusual selenophene ring, which shows both NMDA antagonist effects and with weaker activity as a norepinephrine–dopamine reuptake inhibitor, and has been researched as a potential treatment agent for Fragile X syndrome.[1]


See also

References

  1. ^ Wallach J, Cameron S, Dybek M, Stanley B, Orme C, Riad N, et al. (February 2026). “Bioisostere-Driven Discovery of SePP: A Selenium-Containing Polypharmacological Agent Relevant to Fragile X Syndrome”. Journal of Medicinal Chemistry acs.jmedchem.5c02700. doi:10.1021/acs.jmedchem.5c02700. PMID 41666325.