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Spiroxatrine (Spiroxamide, R5188) is a drug which acts as a selective antagonist at both the 5-HT1A receptor and the α2C adrenergic receptor.[1] It is an analog of spiperone and also has some dopamine antagonist effects and a relatively weak opioid action.[2][3]

References

  1. ^ Terrón, J. A.; Ibarra, M; Ransanz, V; Hong, E; Villalón, C. M. (1993). “The alpha-antiadrenergic properties of spiroxatrine, a ligand of serotonergic 5-HT1A receptors”. Archivos del Instituto de Cardiología de México. 63 (4): 289–95. PMID 8105762.
  2. ^ Niemegeers, CJ; Verbruggen, FJ; Vannueten, JM; Janssen, PA (Dec 1963). “Spiroxamide (R 5188) : A new compound producing morphine-like and chlorpromazine-like effects in animals”. Int J Neuropharmacol. 2 (6): 349–54. doi:10.1016/0028-3908(63)90010-8. PMID 14119495.
  3. ^ Leysen, J; Tollenaere, JP; Koch, MHJ; Laduron, P (1977). “Differentiation of opiate and neuroleptic receptor binding in rat brain”. European Journal of Pharmacology. 43 (3): 253–267. doi:10.1016/0014-2999(77)90025-5. PMID 194781.