Transcription factor 15 (TCF-15) also known as Paraxis, is a protein that in humans is encoded by the TCF15 gene.[5]
Function
Transcription factor 15 is found in the nucleus and is involved in the early transcriptional regulation of patterning of the mesoderm, and has a key role in somitogenesis.[6] The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding. [provided by RefSeq, Jul 2008].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000125878 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068079 – Ensembl, May 2017
- ^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ “Entrez Gene: Transcription factor 15”. Retrieved 2017-11-09.
- ^ “TCF15”. UniProt. Retrieved 29 June 2025.
Further reading
- Guo P, Zhao KW, Dong XY, Sun X, Dong JT (2009). “Acetylation of KLF5 alters the assembly of p15 transcription factors in transforming growth factor-beta-mediated induction in epithelial cells”. J. Biol. Chem. 284 (27): 18184–93. doi:10.1074/jbc.M109.007096. PMC 2709394. PMID 19419955.
- Coppiello G, Collantes M, Sirerol-Piquer MS, Vandenwijngaert S, Schoors S, Swinnen M, Vandersmissen I, Herijgers P, Topal B, van Loon J, Goffin J, Prósper F, Carmeliet P, García-Verdugo JM, Janssens S, Peñuelas I, Aranguren XL, Luttun A (2015). “Meox2/Tcf15 heterodimers program the heart capillary endothelium for cardiac fatty acid uptake”. Circulation. 131 (9): 815–26. doi:10.1161/CIRCULATIONAHA.114.013721. hdl:10550/105619. PMID 25561514.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.