TNP-470 is an methionine aminopeptidase 2 inhibitor. Although it was one of the first angiogenesis inhibitor tested in clinical trials, its potential was hampered by neurotoxic effects and lack of effectiveness.[1][2][3]
References
- ^ Goya Grocin, Andrea; Kallemeijn, Wouter W.; Tate, Edward W. (October 2021). “Targeting methionine aminopeptidase 2 in cancer, obesity, and autoimmunity”. Trends in Pharmacological Sciences. 42 (10): 870–882. doi:10.1016/j.tips.2021.07.004. hdl:10044/1/102175. PMID 34446297. S2CID 237321716.
- ^ Kruger, E. A.; Figg, W. D. (June 2000). “TNP-470: an angiogenesis inhibitor in clinical development for cancer”. Expert Opinion on Investigational Drugs. 9 (6): 1383–1396. doi:10.1517/13543784.9.6.1383. ISSN 1354-3784. PMID 11060750. S2CID 45149960.
- ^ Stadler, Walter M.; Kuzel, Timothy; Shapiro, Charles; Sosman, Jeffery; Clark, Joseph; Vogelzang, Nicholas J. (August 1999). “Multi-Institutional Study of the Angiogenesis Inhibitor TNP-470 in Metastatic Renal Carcinoma”. Journal of Clinical Oncology. 17 (8): 2541–2545. doi:10.1200/JCO.1999.17.8.2541. ISSN 0732-183X. PMID 10561320.