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Tropatepine (brand name Lepticur) is an anticholinergic used as an antiparkinsonian agent.[1]

Synthesis

Tropatepine can be synthesized from 3-chlorotropane (1).[2] A Grignard reaction between 3-chlorotropane and dibenzo[b,e]thiepin-11(6H)-one (2) followed by dehydration to the olefin produces tropatepine (3).

Synthesis of tropatepine

See also

References

  1. ^ Celsis P, Montastruc JL, Rascol O, Senard JM, Marc-Vergnes JP, Rascol A (July 1989). “Effect of tropatepine, an anticholinergic drug, on regional cerebral blood flow in patients with Parkinson’s disease”. Journal of Neurology, Neurosurgery, and Psychiatry. 52 (7): 917–8. doi:10.1136/jnnp.52.7.917. PMC 1031949. PMID 2769291.
  2. ^ DE1952206 idem J Boissier, R Ratouis, U.S. patent 3,725,415 (1973 to Ind Pour La Fab Antibiotiques).