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UCSF648 is an experimental drug which acts as a selective partial agonist for the 5-HT_5A serotonin receptor. Very few selective ligands are available for this receptor, and UCSF648 is expected to be useful in researching its structure and function.^[1]

References

^ Levit Kaplan A, Strachan RT, Braz JM, Craik V, Slocum S, Mangano T, et al. (March 2022). “Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor”. Journal of Medicinal Chemistry. 65 (5): 4201–4217. doi:10.1021/acs.jmedchem.1c02031. PMC 9116900. PMID 35195401.

[rdp-we-cite_note-pmid35195401-1] Levit Kaplan A, Strachan RT, Braz JM, Craik V, Slocum S, Mangano T, et al. (March 2022). “Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor”. Journal of Medicinal Chemistry. 65 (5): 4201–4217. doi:10.1021/acs.jmedchem.1c02031. PMC 9116900. PMID 35195401.

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