Lame may refer to:
- LAME, MP3 encoder
- Lame (armor), a single plate in an articulated piece of plate armour
- Lame (kitchen tool), a small blade for functional and decorative scoring of loaves of bread
- “Lame” (song), song by Unwritten Law
- Lame language, spoken in Nigeria
- Lameness (equine)
- Licensed aircraft maintenance engineer
- Lameness; see physical disability